Across TCGA patient cohorts, SEPTIN10 mutation is significantly associated with the RNA expression of many other genes, with 5,252 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEPTIN10-associated genes across cancer lineages are PACSIN2, TAF6, and SEC13. Each is linked with SEPTIN10 in more than 2 cancer types. Because this analysis shows association rather than direction, both SEPTIN10-to-partner and partner-to-SEPTIN10 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPTIN10→partner) and Y-score (partner→SEPTIN10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PACSIN2 →	+0.673	+2.523	<.001	<.001	3	3
UCEC	TAF6 →	+0.490	+3.732	.003	<.001	3	3
UCEC	SEC13 →	+0.362	+3.732	.001	<.001	3	3
UCEC	GPX4 →	+0.374	+1.568	.009	.009	3	3
UCEC	RPS29P32 →	+0.360	+2.084	<.001	.002	3	2
UCEC	ZNF852 →	+0.463	+3.032	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,252 associations by consensus.

Exploration

SEPTIN10 survival (RNA) · tumor vs normal (RNA) · all SEPTIN10 data types