SEPSECS

Across TCGA pan-cancer cohorts, SEPSECS Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SEPSECS data layer compared with 24 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in thyroid carcinoma (THCA), where higher SEPSECS Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SEPSECS expression acts as an unfavorable survival marker.

THCA, LUSC, and ACC are the cancer types where SEPSECS Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	DFS	Median	All	0.178	0.842	.010	6	view →
LUSC	OS	Median	All	0.449	0.777	.031	6	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SEPSECS–THCA (DFS)

Open the THCA breakdown →