SEPSECS

Across TCGA patient cohorts, SEPSECS RNA expression is significantly associated with the protein abundance of many other proteins, with 14,352 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SEPSECS-associated proteins across cancer lineages are HTT, NELFA, and EIF5B_S1168. Each is linked with SEPSECS in more than 5 cancer types. Because this analysis shows association rather than direction, both SEPSECS-to-partner and partner-to-SEPSECS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SEPSECS versus HTT in OV, with a Pearson correlation of 0.38.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPSECS→partner) and Y-score (partner→SEPSECS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	HTT →	+0.260	+0.540	.002	.001	3	6
LUAD	NELFA →	+0.233	+0.429	<.001	<.001	3	6
BRCA	EIF5B_S1168 →	-0.571	-0.648	<.001	<.001	3	5
GBM	RPL14 →	-0.568	-0.407	<.001	<.001	3	5
GBM	RPL7 →	-0.439	-0.354	<.001	<.001	3	5
GBM	RPS6 →	-0.497	-0.410	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,352 associations by consensus.

SEPSECS vs HTT — OV

Explore this scatter interactively →