SEPSECS

Across TCGA patient cohorts, SEPSECS protein abundance is significantly associated with the RNA expression of many other genes, with 15,050 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SEPSECS-associated genes across cancer lineages are GLRX3, HMGA1, and GARS1. Each is linked with SEPSECS in more than 6 cancer types. Because this analysis shows association rather than direction, both SEPSECS-to-partner and partner-to-SEPSECS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SEPSECS versus GLRX3 in BRCA, with a Pearson correlation of -0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPSECS→partner) and Y-score (partner→SEPSECS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GLRX3 →	-0.426	-0.258	<.001	.004	3	7
UCEC	HMGA1 →	-0.980	-0.335	<.001	<.001	3	6
BRCA	GARS1 →	-0.531	-0.264	<.001	<.001	3	6
PDAC	AMY2B →	+1.659	+0.229	<.001	.002	3	5
LSCC	PKP1 →	-1.635	-0.206	.003	<.001	3	5
BRCA	SLC7A5 →	-1.469	-0.414	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,050 associations by consensus.

SEPSECS vs GLRX3 — BRCA

Explore this scatter interactively →