SEPSECS

Across TCGA patient cohorts, SEPSECS mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEPSECS-associated genes across cancer lineages are MEK1, ACC1, and JNK_pT183_Y185. Each is linked with SEPSECS in more than 1 cancer types. Because this analysis shows association rather than direction, both SEPSECS-to-partner and partner-to-SEPSECS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by SEPSECS-low versus SEPSECS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPSECS→partner) and Y-score (partner→SEPSECS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.481	+2.584	.004	.011	3	2
UCEC	ACC1 →	+0.463	+2.584	.006	.011	3	1
UCEC	JNK_pT183_Y185 →	-0.190	-3.000	.015	.036	3	1
UCEC	PDCD4 →	-0.737	-2.584	<.001	.011	3	1
UCEC	PKC-b-II_pS660 →	-0.260	-3.000	.043	.036	3	1
UCEC	TIGAR →	+0.273	+1.901	<.001	.031	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

MEK1 by SEPSECS expression — UCEC

Explore this box plot interactively →