SEPSECS

Across TCGA cell cohorts, SEPSECS RNA expression is significantly associated with the go_rna of many other GO terms, with 3,495 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SEPSECS-associated GO terms across cancer lineages are L-selenocysteine biosynthetic process, Vesicle tethering, and Cilium or flagellum-dependent cell motility. Each is linked with SEPSECS in more than 12 cancer types. Because this analysis shows association rather than direction, both SEPSECS-to-partner and partner-to-SEPSECS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, L-selenocysteine biosynthetic process grouped by SEPSECS-low versus SEPSECS-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPSECS→partner) and Y-score (partner→SEPSECS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	L-selenocysteine biosynthetic process →	-0.156	-1.063	<.001	<.001	3	13
BREAST	Vesicle tethering →	+0.071	+0.554	.001	.001	3	12
URINARY_TRACT	Cilium or flagellum-dependent cell motility →	-0.107	-0.760	<.001	.001	3	11
BREAST	Positive regulation of organelle assembly →	+0.061	+0.670	<.001	<.001	2	12
URINARY_TRACT	Cilium-dependent cell motility →	-0.107	-0.760	<.001	.001	3	11
URINARY_TRACT	Cilium movement involved in cell motility →	-0.118	-0.824	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,495 associations by consensus.

L-selenocysteine biosynthetic process by SEPSECS expression — STOMACH

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