SEPSECS

Across TCGA cell cohorts, SEPSECS mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SEPSECS-associated genes across cancer lineages are CLEC9A, NPVF, and OR4D5. Each is linked with SEPSECS in more than 1 cancer types. Because this analysis shows association rather than direction, both SEPSECS-to-partner and partner-to-SEPSECS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLEC9A grouped by SEPSECS-low versus SEPSECS-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPSECS→partner) and Y-score (partner→SEPSECS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CLEC9A →	+0.012	+4.977	<.001	.007	3	1
LUNG_NSCLC_LUAD	NPVF →	+0.014	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR4D5 →	+0.014	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	PRR23B →	+0.004	+4.662	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

CLEC9A by SEPSECS expression — LARGE_INTESTINE

Explore this box plot interactively →