SEPHS2P1

Across TCGA pan-cancer cohorts, SEPHS2P1 RNA is linked to patient survival in 9 of 34 cancer types, making it the most broadly survival-associated SEPHS2P1 data layer.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SEPHS2P1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SEPHS2P1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

LUAD, DLBC, and CESC are the cancer types where SEPHS2P1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	III,IV	0.438	0.725	<.001	59	view →
DLBC	OS	Tertile	III,IV	0.175	0.874	.025	36	view →
CESC	OS	Quartile	All	0.774	0.901	<.001	36	view →
KICH	DFS	Quartile	All	0.691	1.000	.008	27	view →
SARC	DFS	Tertile	All	0.400	0.631	.005	18	view →
TGCT	DFS	Tertile	All	0.694	0.865	.019	12	view →
HNSC	DFS	Tertile	II,III,IV	0.495	0.281	.020	6	view →
THCA	OS	Tertile	III,IV	0.950	0.981	.048	3	view →
BRCA	OS	Tertile	All	0.676	0.546	.043	2	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

SEPHS2P1–LUAD (OS)

Open the LUAD breakdown →