SEPHS2

Across TCGA pan-cancer cohorts, SEPHS2 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SEPHS2 data layer compared with 22 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher SEPHS2 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SEPHS2 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

SKCM and UCEC are the cancer types where SEPHS2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	III,IV	0.088	0.613	.018	6	view →
UCEC	DFS	Median	All	1.000	0.631	.039	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

SEPHS2–SKCM (DFS)

Open the SKCM breakdown →