SEPHS2

Across TCGA patient cohorts, SEPHS2 protein abundance is significantly associated with the RNA expression of many other genes, with 13,275 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SEPHS2-associated genes across cancer lineages are HJURP, CKAP2L, and PRR11. Each is linked with SEPHS2 in more than 6 cancer types. Because this analysis shows association rather than direction, both SEPHS2-to-partner and partner-to-SEPHS2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SEPHS2 versus HJURP in GBM, with a Pearson correlation of -0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPHS2→partner) and Y-score (partner→SEPHS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HJURP →	-1.074	-0.245	<.001	<.001	3	7
GBM	CKAP2L →	-0.864	-0.238	<.001	<.001	3	7
UCEC	PRR11 →	-0.952	-0.297	<.001	<.001	3	7
BRCA	MCM5 →	-0.741	-0.354	<.001	.002	3	6
OV	CDKN3 →	-1.075	-0.313	.001	<.001	3	6
BRCA	UBE2S →	-1.158	-0.431	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,275 associations by consensus.

SEPHS2 vs HJURP — GBM

Explore this scatter interactively →