SEPHS2

Across TCGA patient cohorts, SEPHS2 mutation is significantly associated with the RNA expression of many other genes, with 1,867 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEPHS2-associated genes across cancer lineages are MIR6846, MIR4510, and RNU6-142P. Each is linked with SEPHS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEPHS2-to-partner and partner-to-SEPHS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6846 grouped by SEPHS2-low versus SEPHS2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPHS2→partner) and Y-score (partner→SEPHS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR6846 →	+0.351	+8.055	<.001	.007	3	2
CESC	MIR4510 →	+0.236	+4.757	<.001	.004	3	2
HNSC	RNU6-142P →	+0.315	+4.655	<.001	.007	3	2
HNSC	RNU6-136P →	+0.417	+4.480	.001	.005	3	2
LIHC	BIN2P2 →	+0.069	+5.268	<.001	.006	3	2
CESC	RNU4-31P →	+0.319	+5.289	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,867 associations by consensus.

MIR6846 by SEPHS2 expression — BRCA

Explore this box plot interactively →