SEPHS2

Across TCGA patient cohorts, SEPHS2 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEPHS2-associated genes across cancer lineages are EGFR_pY1068, ERK2, and FOXO3a_pS318_S321. Each is linked with SEPHS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEPHS2-to-partner and partner-to-SEPHS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by SEPHS2-low versus SEPHS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPHS2→partner) and Y-score (partner→SEPHS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.282	-3.000	.025	.036	3	1
UCEC	ERK2 →	+0.274	+2.321	.004	.035	3	1
UCEC	FOXO3a_pS318_S321 →	-0.177	-2.321	.004	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.274	-2.999	.001	.035	3	1
UCEC	mTOR_pS2448 →	-0.196	-2.980	.008	.036	3	1
UCEC	P-Cadherin →	-0.171	-2.999	.018	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

EGFR_pY1068 by SEPHS2 expression — UCEC

Explore this box plot interactively →