SEPHS2

Across TCGA cell cohorts, SEPHS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,373 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SEPHS2-associated GO terms across cancer lineages are L-selenocysteine biosynthetic process, Symbiont-mediated disruption of host cell PML body, and Positive regulation of proteasomal protein catabolic process. Each is linked with SEPHS2 in more than 17 cancer types. Because this analysis shows association rather than direction, both SEPHS2-to-partner and partner-to-SEPHS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, L-selenocysteine biosynthetic process grouped by SEPHS2-low versus SEPHS2-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPHS2→partner) and Y-score (partner→SEPHS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	L-selenocysteine biosynthetic process →	+0.171	+1.427	<.001	<.001	3	18
BREAST	Symbiont-mediated disruption of host cell PML body →	+0.083	+0.930	.004	.001	2	10
SOFT_TISSUE	Positive regulation of proteasomal protein catabolic process →	+0.049	+0.619	<.001	<.001	3	9
BONE	Regulation of chromatin organization →	+0.110	+0.334	.004	.005	3	9
KIDNEY	Lysosomal lumen acidification →	+0.120	+0.850	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Synaptic vesicle lumen acidification →	+0.147	+1.060	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,373 associations by consensus.

L-selenocysteine biosynthetic process by SEPHS2 expression — PANCREAS

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