SEPHS2

Across TCGA cell cohorts, SEPHS2 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SEPHS2-associated genes across cancer lineages are GFRA4, CALHM4, and OR10K2. Each is linked with SEPHS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEPHS2-to-partner and partner-to-SEPHS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GFRA4 grouped by SEPHS2-low versus SEPHS2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPHS2→partner) and Y-score (partner→SEPHS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GFRA4 →	+0.308	+4.409	<.001	.005	3	1
BLOOD_Leukemia	CALHM4 →	+0.038	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	OR10K2 →	+0.060	+4.705	<.001	.003	3	1
BLOOD_Leukemia	OR10T2 →	+0.889	+4.276	<.001	.007	3	1
BLOOD_Leukemia	OR10R2 →	+1.909	+4.551	<.001	.004	3	1
BLOOD_Leukemia	TSSK1B →	+0.014	+4.874	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

GFRA4 by SEPHS2 expression — BLOOD_Leukemia

Explore this box plot interactively →