SEPHS1P1

Across TCGA patient cohorts, SEPHS1P1 mutation is significantly associated with the RNA expression of many other genes, with 2,533 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEPHS1P1-associated genes across cancer lineages are RNU6-1164P, ATP8A2P1, and RNU6-1089P. Each is linked with SEPHS1P1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEPHS1P1-to-partner and partner-to-SEPHS1P1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1164P grouped by SEPHS1P1-low versus SEPHS1P1-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPHS1P1→partner) and Y-score (partner→SEPHS1P1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	RNU6-1164P →	+0.465	+4.415	<.001	.006	3	2
LIHC	ATP8A2P1 →	+0.789	+4.240	.001	.008	3	2
LIHC	RNU6-1089P →	+0.515	+4.964	<.001	.002	3	2
LUSC	TRAJ29 →	+0.481	+4.417	<.001	.002	3	2
LUSC	LINC02508 →	+0.191	+4.393	<.001	.008	3	2
UCEC	ZNF746 →	+0.549	+3.617	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,533 associations by consensus.

RNU6-1164P by SEPHS1P1 expression — LIHC

Explore this box plot interactively →