SEPHS1

Across TCGA pan-cancer cohorts, SEPHS1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SEPHS1 data layer compared with 28 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher SEPHS1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SEPHS1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

OV, STAD, and UCEC are the cancer types where SEPHS1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	All	0.362	0.842	.005	18	view →
STAD	OS	Median	All	0.119	0.539	.038	3	view →
UCEC	DFS	Median	All	0.937	0.828	.047	2	view →
SKCM	OS	Median	All	0.123	0.326	.017	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SEPHS1–OV (OS)

Open the OV breakdown →