SEPHS1

Across TCGA pan-cancer cohorts, SEPHS1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SEPHS1 data layer compared with 28 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SEPHS1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SEPHS1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

PDAC, HNSC, and LUAD are the cancer types where SEPHS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	II,III,IV	0.745	0.336	.002	28	view →
HNSC	DFS	Tertile	All	0.463	0.741	.001	22	view →
LUAD	OS	Tertile	All	0.989	0.535	.001	20	view →
CCRCC	OS	Tertile	All	0.935	0.707	.004	13	view →
OV	DFS	Median	All	0.862	1.000	.031	4	view →
GBM	DFS	Quartile	All	0.425	0.171	.040	2	view →
LSCC	DFS	Quartile	All	0.649	0.920	.029	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SEPHS1–PDAC (DFS)

Open the PDAC breakdown →