SEPHS1

Across TCGA pan-cancer cohorts, SEPHS1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of SEPHS1’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where SEPHS1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types SEPHS1 is over-expressed in tumor, although a few such as PDAC and LUAD show the opposite, repressed pattern.

PDAC, LUAD, and HNSC are the cancer types where SEPHS1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEPHS1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Female	II,III,IV	−0.359	<.001	8	view →
LUAD	Female	II,III,IV	−0.138	<.001	6	view →
HNSC	All	All	−0.080	.010	5	view →
OV	All	All	+0.392	.034	2	view →
LSCC	All	All	−0.058	.043	2	view →
CCRCC	Male	III,IV	−0.061	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

SEPHS1–PDAC

Open the PDAC breakdown →