SEPHS1

Across TCGA patient cohorts, SEPHS1 RNA expression is significantly associated with the protein abundance of many other proteins, with 17,469 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SEPHS1-associated proteins across cancer lineages are UPF2, RNF20, and KIN. Each is linked with SEPHS1 in more than 6 cancer types. Because this analysis shows association rather than direction, both SEPHS1-to-partner and partner-to-SEPHS1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SEPHS1 versus UPF2 in BRCA, with a Pearson correlation of 0.69.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPHS1→partner) and Y-score (partner→SEPHS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	UPF2 →	+0.293	+0.711	<.001	<.001	3	7
LSCC	RNF20 →	+0.330	+0.959	<.001	<.001	3	7
OV	KIN →	+0.364	+0.598	<.001	<.001	3	7
BRCA	U2SURP →	+0.338	+0.629	<.001	<.001	3	6
LSCC	MTA1_S576 →	+0.685	+0.757	.005	<.001	3	6
GBM	WAS →	-0.417	-0.447	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,469 associations by consensus.

SEPHS1 vs UPF2 — BRCA

Explore this scatter interactively →