SEPHS1

Across TCGA patient cohorts, SEPHS1 protein abundance is significantly associated with the RNA expression of many other genes, with 9,149 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SEPHS1-associated genes across cancer lineages are SOD2, PRPF18, and UPF2. Each is linked with SEPHS1 in more than 5 cancer types. Because this analysis shows association rather than direction, both SEPHS1-to-partner and partner-to-SEPHS1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SEPHS1 versus SOD2 in GBM, with a Pearson correlation of -0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPHS1→partner) and Y-score (partner→SEPHS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SOD2 →	-0.887	-0.199	<.001	<.001	3	6
HNSC	PRPF18 →	+0.600	+0.183	<.001	<.001	3	6
BRCA	UPF2 →	+0.520	+0.302	<.001	<.001	3	5
OV	NCF2 →	-0.735	-0.444	.005	.004	3	5
GBM	NAMPT →	-0.781	-0.168	.001	<.001	3	4
HNSC	ANKRD16 →	+0.592	+0.190	<.001	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,149 associations by consensus.

SEPHS1 vs SOD2 — GBM

Explore this scatter interactively →