SEPHS1

Across TCGA patient cohorts, SEPHS1 mutation is significantly associated with the RNA expression of many other genes, with 3,130 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEPHS1-associated genes across cancer lineages are RPL31P54, PMS2P11, and TPT1P11. Each is linked with SEPHS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SEPHS1-to-partner and partner-to-SEPHS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL31P54 grouped by SEPHS1-low versus SEPHS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPHS1→partner) and Y-score (partner→SEPHS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPL31P54 →	+0.071	+1.961	.007	.004	3	3
SKCM	PMS2P11 →	+0.078	+2.754	<.001	.009	3	3
CESC	TPT1P11 →	+0.087	+5.418	<.001	.005	3	2
UCEC	MFAP2 →	-0.958	-4.311	<.001	<.001	3	2
UCEC	MTHFD1L →	+0.390	+2.258	.005	<.001	3	2
UCEC	IMPA2 →	+0.507	+1.847	.003	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,130 associations by consensus.

RPL31P54 by SEPHS1 expression — UCEC

Explore this box plot interactively →