SEPHS1

Across TCGA patient cohorts, SEPHS1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEPHS1-associated genes across cancer lineages are MEK1, 4E-BP1_pT37_T46, and 14-3-3_beta. Each is linked with SEPHS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEPHS1-to-partner and partner-to-SEPHS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by SEPHS1-low versus SEPHS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPHS1→partner) and Y-score (partner→SEPHS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.447	+2.378	<.001	<.001	3	2
UCEC	4E-BP1_pT37_T46 →	-0.285	-2.102	.017	.016	3	2
UCEC	14-3-3_beta →	-0.065	-1.847	.041	.049	3	1
UCEC	EGFR_pY1068 →	-0.175	-1.289	.029	.023	3	1
UCEC	eIF4E →	+0.169	+2.598	.012	.005	3	1
UCEC	ER-alpha_pS118 →	-0.243	-1.523	.034	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

MEK1 by SEPHS1 expression — UCEC

Explore this box plot interactively →