SEPHS1

Across TCGA cell cohorts, SEPHS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,984 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SEPHS1-associated GO terms across cancer lineages are DNA replication initiation, Lagging strand elongation, and Chromosome segregation. Each is linked with SEPHS1 in more than 16 cancer types. Because this analysis shows association rather than direction, both SEPHS1-to-partner and partner-to-SEPHS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication initiation grouped by SEPHS1-low versus SEPHS1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPHS1→partner) and Y-score (partner→SEPHS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DNA replication initiation →	+0.166	+1.241	<.001	<.001	3	17
STOMACH	Lagging strand elongation →	+0.129	+0.712	<.001	<.001	3	17
SOFT_TISSUE	Chromosome segregation →	+0.082	+0.872	.006	<.001	3	17
BREAST	Regulation of mitotic sister chromatid separation →	+0.170	+1.008	<.001	<.001	3	16
BREAST	Regulation of metaphase/anaphase transition of cell cycle →	+0.139	+1.068	<.001	<.001	3	16
BREAST	Regulation of chromosome separation →	+0.171	+1.087	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,984 associations by consensus.

DNA replication initiation by SEPHS1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →