SEPHS1

Across TCGA cell cohorts, SEPHS1 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SEPHS1-associated genes across cancer lineages are ETNPPL, FAM205A, and NEXMIF. Each is linked with SEPHS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEPHS1-to-partner and partner-to-SEPHS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ETNPPL grouped by SEPHS1-low versus SEPHS1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPHS1→partner) and Y-score (partner→SEPHS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ETNPPL →	+0.215	+3.758	.003	.004	3	1
LARGE_INTESTINE	FAM205A →	+0.019	+3.766	.001	.004	3	1
LARGE_INTESTINE	NEXMIF →	+0.202	+3.196	.001	.007	3	1
LARGE_INTESTINE	ADAM7 →	+0.004	+3.345	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

ETNPPL by SEPHS1 expression — LARGE_INTESTINE

Explore this box plot interactively →