SENP8

Across TCGA pan-cancer cohorts, SENP8 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SENP8 data layer compared with 21 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SENP8 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SENP8 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

LSCC, UCEC, and CCRCC are the cancer types where SENP8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	III,IV	0.561	1.000	.012	19	view →
UCEC	DFS	Quartile	III,IV	0.427	1.000	.040	8	view →
CCRCC	OS	Quartile	All	0.915	0.404	.018	7	view →
LUAD	DFS	Tertile	II,III,IV	0.738	0.994	.005	6	view →
PDAC	OS	Tertile	IV	0.472	0.962	.024	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SENP8–LSCC (DFS)

Open the LSCC breakdown →