SENP8

Across TCGA pan-cancer cohorts, SENP8 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of SENP8’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where SENP8 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types SENP8 is over-expressed in tumor, although a few such as CCRCC and HNSC show the opposite, repressed pattern.

CCRCC, HNSC, and COAD are the cancer types where SENP8 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SENP8 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	All	IV	−0.520	<.001	12	view →
HNSC	Male	II,III,IV	−0.498	<.001	11	view →
COAD	Male	II,III,IV	−0.674	<.001	9	view →
LSCC	Female	II,III,IV	−0.607	<.001	9	view →
LUAD	Male	III,IV	−0.528	<.001	9	view →
PDAC	Male	IV	−0.130	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

SENP8–CCRCC

Open the CCRCC breakdown →