SENP8

Across TCGA cell cohorts, SENP8 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,423 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SENP8-associated GO terms across cancer lineages are Vesicle budding from membrane, COPII-coated vesicle budding, and Regulation of heterochromatin organization. Each is linked with SENP8 in more than 11 cancer types. Because this analysis shows association rather than direction, both SENP8-to-partner and partner-to-SENP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Vesicle budding from membrane grouped by SENP8-low versus SENP8-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SENP8→partner) and Y-score (partner→SENP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Vesicle budding from membrane →	+0.066	+0.360	<.001	.001	3	12
CNS	COPII-coated vesicle budding →	+0.074	+0.372	<.001	<.001	3	10
LUNG_SCLC	Regulation of heterochromatin organization →	+0.108	+0.356	<.001	.003	3	10
BLOOD_Leukemia	Regulation of myoblast fusion →	+0.084	+0.429	<.001	<.001	3	9
SOFT_TISSUE	mRNA 3'-end processing →	+0.069	+0.406	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	ATP synthesis coupled electron transport →	+0.074	+0.527	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,423 associations by consensus.

Vesicle budding from membrane by SENP8 expression — SKIN

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