SENP8

Across TCGA cell cohorts, SENP8 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SENP8-associated genes across cancer lineages are PATE4, OR6Q1, and C1QTNF7. Each is linked with SENP8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SENP8-to-partner and partner-to-SENP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PATE4 grouped by SENP8-low versus SENP8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SENP8→partner) and Y-score (partner→SENP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PATE4 →	+0.041	+4.095	<.001	.009	3	1
LARGE_INTESTINE	OR6Q1 →	+0.022	+5.022	<.001	.002	3	1
LARGE_INTESTINE	C1QTNF7 →	+0.123	+4.108	<.001	.008	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

PATE4 by SENP8 expression — LARGE_INTESTINE

Explore this box plot interactively →