SENP7

Across TCGA patient cohorts, SENP7 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SENP7-associated genes across cancer lineages are Cyclin-B1, PDCD4, and ATM. Each is linked with SENP7 in more than 3 cancer types. Because this analysis shows association rather than direction, both SENP7-to-partner and partner-to-SENP7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by SENP7-low versus SENP7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SENP7→partner) and Y-score (partner→SENP7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.718	+3.906	<.001	<.001	3	4
UCEC	PDCD4 →	-0.556	-1.584	<.001	.005	3	3
UCEC	ATM →	-0.496	-2.247	<.001	.001	3	3
UCEC	Di-Ras3 →	-0.128	-1.584	.006	.005	3	3
UCEC	MEK1 →	+0.492	+2.807	<.001	<.001	3	2
UCEC	p62 Lck ligand →	+0.242	+1.584	.018	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Cyclin-B1 by SENP7 expression — UCEC

Explore this box plot interactively →