SENP7

Across TCGA cell cohorts, SENP7 mutation is significantly associated with the RNA expression of many other genes, with 660 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SENP7-associated genes across cancer lineages are ZIC3, SLC25A17, and FZD3. Each is linked with SENP7 in more than 1 cancer types. Because this analysis shows association rather than direction, both SENP7-to-partner and partner-to-SENP7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZIC3 grouped by SENP7-low versus SENP7-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SENP7→partner) and Y-score (partner→SENP7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZIC3 →	+0.009	+3.153	<.001	.002	3	2
LARGE_INTESTINE	SLC25A17 →	+0.643	+3.743	<.001	<.001	3	2
LARGE_INTESTINE	FZD3 →	+0.812	+2.628	<.001	.002	3	2
LARGE_INTESTINE	MTMR4 →	+0.703	+3.169	.001	.006	3	2
LARGE_INTESTINE	UFSP2 →	+0.628	+3.743	<.001	<.001	3	2
LARGE_INTESTINE	PTCD3 →	+0.544	+3.234	.003	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 660 associations by consensus.

ZIC3 by SENP7 expression — BLOOD_Leukemia

Explore this box plot interactively →