SENP7

Across TCGA cell cohorts, SENP7 mutation is significantly associated with the mutation status of many other genes, with 4,780 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SENP7-associated genes across cancer lineages are ADCY1, HCN1, and DCAF5. Each is linked with SENP7 in more than 5 cancer types. Because this analysis shows association rather than direction, both SENP7-to-partner and partner-to-SENP7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADCY1 grouped by SENP7-low versus SENP7-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SENP7→partner) and Y-score (partner→SENP7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ADCY1 →	+1.773	+2.064	.002	.002	1	6
LARGE_INTESTINE	HCN1 →	+2.148	+1.989	.003	.003	1	5
CNS	DCAF5 →	+4.459	+5.277	.005	.005	1	4
URINARY_TRACT	ADAMTS16 →	+3.087	+4.000	.008	.008	1	4
URINARY_TRACT	ADGRV1 →	+3.087	+4.000	.008	.008	1	4
BLOOD_Leukemia	TDRD12 →	+3.498	+3.063	.006	.006	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,780 associations by consensus.

ADCY1 by SENP7 expression — LARGE_INTESTINE

Explore this box plot interactively →