SENP5

Across TCGA pan-cancer cohorts, SENP5 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SENP5 data layer compared with 28 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SENP5 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SENP5 expression acts as an unfavorable survival marker.

PDAC, LUAD, and CCRCC are the cancer types where SENP5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	III,IV	0.594	0.988	.001	45	view →
LUAD	DFS	Median	All	0.508	1.000	<.001	16	view →
CCRCC	DFS	Median	II,III,IV	0.078	0.856	.038	6	view →
LSCC	OS	Median	III,IV	0.469	0.866	.008	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SENP5–PDAC (DFS)

Open the PDAC breakdown →