SENP5

Across TCGA cell cohorts, SENP5 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,230 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SENP5-associated GO terms across cancer lineages are Protein sumoylation, Positive regulation of mRNA metabolic process, and Protein desumoylation. Each is linked with SENP5 in more than 17 cancer types. Because this analysis shows association rather than direction, both SENP5-to-partner and partner-to-SENP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein sumoylation grouped by SENP5-low versus SENP5-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SENP5→partner) and Y-score (partner→SENP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Protein sumoylation →	+0.082	+0.722	<.001	.001	3	18
STOMACH	Positive regulation of mRNA metabolic process →	+0.082	+0.721	<.001	<.001	3	18
URINARY_TRACT	Protein desumoylation →	+0.093	+0.608	<.001	<.001	2	18
STOMACH	Regulation of mRNA catabolic process →	+0.055	+0.576	<.001	.001	3	17
STOMACH	Protein modification by small protein removal →	+0.056	+0.653	.006	.005	2	18
LUNG_NSCLC_LUAD	Negative regulation of macroautophagy →	+0.076	+0.693	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,230 associations by consensus.

Protein sumoylation by SENP5 expression — SOFT_TISSUE

Explore this box plot interactively →