SENP5

Across TCGA cell cohorts, SENP5 mutation is significantly associated with the drug of many other genes, with 39 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SENP5-associated genes across cancer lineages are JAK1_8709, MK-8776, and 5-Fluorouracil. Each is linked with SENP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SENP5-to-partner and partner-to-SENP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JAK1_8709 grouped by SENP5-low versus SENP5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SENP5→partner) and Y-score (partner→SENP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	JAK1_8709 →	+0.433	+3.234	.011	.004	3	2
LARGE_INTESTINE	MK-8776 →	+0.537	+2.807	.042	.044	3	2
LARGE_INTESTINE	5-Fluorouracil →	+0.617	+2.184	.013	.030	3	1
LARGE_INTESTINE	Serdemetan →	+0.373	+3.125	.009	.008	3	1
LARGE_INTESTINE	MK-1775 →	+0.327	+2.061	.020	.036	3	1
LARGE_INTESTINE	AZD5153 →	+0.617	+2.932	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

JAK1_8709 by SENP5 expression — LARGE_INTESTINE

Explore this box plot interactively →