SENP3

Across TCGA patient cohorts, SENP3 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SENP3-associated genes across cancer lineages are JNK2, Chk2_pT68, and eIF4E. Each is linked with SENP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SENP3-to-partner and partner-to-SENP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by SENP3-low versus SENP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SENP3→partner) and Y-score (partner→SENP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.246	+1.925	<.001	.005	3	2
UCEC	Chk2_pT68 →	-0.137	-2.295	.041	.033	3	2
UCEC	eIF4E →	+0.164	+3.183	.031	.009	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.394	+1.594	.031	.042	3	1
UCEC	INPP4B →	-0.267	-1.906	.021	.015	3	1
UCEC	Notch1 →	+0.151	+1.817	.002	.015	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

JNK2 by SENP3 expression — UCEC

Explore this box plot interactively →