SENP3

Across TCGA cell cohorts, SENP3 mutation is significantly associated with the drug of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SENP3-associated genes across cancer lineages are CX-5461, 50869, and TAK-715. Each is linked with SENP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SENP3-to-partner and partner-to-SENP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CX-5461 grouped by SENP3-low versus SENP3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SENP3→partner) and Y-score (partner→SENP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CX-5461 →	+0.603	+2.652	.041	.045	3	1
LARGE_INTESTINE	50869 →	+0.513	+2.649	.014	.046	1	1
LARGE_INTESTINE	TAK-715 →	+0.486	+2.786	.019	.037	1	1
LARGE_INTESTINE	GSK429286A →	+0.344	+2.652	.027	.045	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

CX-5461 by SENP3 expression — LARGE_INTESTINE

Explore this box plot interactively →