SENP2

Across TCGA pan-cancer cohorts, SENP2 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of SENP2’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where SENP2 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types SENP2 is over-expressed in tumor, although a few such as CCRCC show the opposite, repressed pattern.

LSCC, PDAC, and CCRCC are the cancer types where SENP2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SENP2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	III,IV	+0.566	<.001	8	view →
PDAC	Female	All	+0.337	.037	2	view →
CCRCC	Male	III,IV	−0.156	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

SENP2–LSCC

Open the LSCC breakdown →