SENP2

Across TCGA patient cohorts, SENP2 mutation is significantly associated with the RNA expression of many other genes, with 2,104 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SENP2-associated genes across cancer lineages are RN7SKP260, MIR3978, and C14orf177. Each is linked with SENP2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SENP2-to-partner and partner-to-SENP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP260 grouped by SENP2-low versus SENP2-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SENP2→partner) and Y-score (partner→SENP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RN7SKP260 →	+1.526	+5.124	<.001	.008	3	4
HNSC	MIR3978 →	+1.127	+5.655	<.001	.004	3	4
BRCA	C14orf177 →	+0.043	+4.610	<.001	.008	3	3
HNSC	PSMA5P1 →	+0.260	+6.763	<.001	<.001	3	3
HNSC	NDUFA5P5 →	+0.567	+5.435	<.001	.005	3	3
HNSC	OR4N1P →	+0.092	+5.368	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,104 associations by consensus.

RN7SKP260 by SENP2 expression — HNSC

Explore this box plot interactively →