SENP2

Across TCGA patient cohorts, SENP2 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SENP2-associated genes across cancer lineages are c-Met_pY1235, EGFR_pY1068, and Acetyl-a-Tubulin-Lys40. Each is linked with SENP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SENP2-to-partner and partner-to-SENP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by SENP2-low versus SENP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SENP2→partner) and Y-score (partner→SENP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.066	+1.415	.017	.046	3	2
UCEC	EGFR_pY1068 →	-0.210	-1.415	.026	.046	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.375	+1.415	.049	.046	3	1
UCEC	INPP4B →	-0.305	-2.700	.012	.006	3	1
UCEC	IRS1 →	+0.166	+1.415	.032	.046	3	1
UCEC	ACVRL1 →	-0.104	-2.446	.041	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

c-Met_pY1235 by SENP2 expression — UCEC

Explore this box plot interactively →