SENP2

Across TCGA cell cohorts, SENP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,622 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SENP2-associated GO terms across cancer lineages are Maintenance of centrosome location, RNA destabilization, and mRNA destabilization. Each is linked with SENP2 in more than 15 cancer types. Because this analysis shows association rather than direction, both SENP2-to-partner and partner-to-SENP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Maintenance of centrosome location grouped by SENP2-low versus SENP2-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SENP2→partner) and Y-score (partner→SENP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Maintenance of centrosome location →	+0.121	+1.060	<.001	<.001	3	16
LUNG_SCLC	RNA destabilization →	+0.050	+0.569	.002	<.001	3	15
LUNG_SCLC	mRNA destabilization →	+0.059	+0.690	.003	<.001	3	15
SOFT_TISSUE	Protein modification by small protein removal →	+0.053	+0.819	.002	.001	2	15
BLOOD_Lymphoma	Positive regulation of mRNA metabolic process →	+0.050	+0.943	.002	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Regulation of syncytium formation by plasma membrane fusion →	+0.109	+0.971	<.001	.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,622 associations by consensus.

Maintenance of centrosome location by SENP2 expression — OVARY

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