SENP1

Across TCGA pan-cancer cohorts, SENP1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SENP1 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SENP1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SENP1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, CCRCC, and HNSC are the cancer types where SENP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	All	0.888	0.585	<.001	54	view →
CCRCC	OS	Tertile	All	0.886	1.000	.015	14	view →
HNSC	OS	Median	III,IV	0.787	0.917	.023	3	view →
PDAC	OS	Median	II,III,IV	0.401	0.540	.045	2	view →
LUAD	OS	Quartile	All	1.000	0.717	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SENP1–LSCC (DFS)

Open the LSCC breakdown →