SENP1

Across TCGA patient cohorts, SENP1 mutation is significantly associated with the RNA expression of many other genes, with 4,208 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SENP1-associated genes across cancer lineages are RNA5SP38, HNRNPMP2, and NDUFA5P6. Each is linked with SENP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SENP1-to-partner and partner-to-SENP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP38 grouped by SENP1-low versus SENP1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SENP1→partner) and Y-score (partner→SENP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNA5SP38 →	+0.194	+4.317	<.001	.007	3	2
CESC	HNRNPMP2 →	+0.047	+4.757	<.001	.004	3	2
STAD	NDUFA5P6 →	+0.830	+3.873	<.001	.004	3	2
SKCM	RNA5SP106 →	+0.153	+4.212	<.001	.007	3	2
SKCM	BCAR1P2 →	+0.050	+3.180	<.001	.004	3	2
SKCM	GLUD1P4 →	+0.092	+3.186	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,208 associations by consensus.

RNA5SP38 by SENP1 expression — BRCA

Explore this box plot interactively →