SENP1

Across TCGA patient cohorts, SENP1 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SENP1-associated genes across cancer lineages are MEK1, Rad50, and ATM. Each is linked with SENP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SENP1-to-partner and partner-to-SENP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by SENP1-low versus SENP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SENP1→partner) and Y-score (partner→SENP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.296	+2.263	.014	<.001	3	2
UCEC	Rad50 →	-0.184	-1.938	.021	.001	3	2
UCEC	ATM →	-0.319	-1.652	.032	.006	3	2
UCEC	FOXO3a_pS318_S321 →	-0.087	-1.392	.033	.019	3	1
UCEC	HER3_pY1289 →	+0.059	+1.678	.039	.003	3	1
UCEC	IGFBP2 →	-0.629	-1.584	.003	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

MEK1 by SENP1 expression — UCEC

Explore this box plot interactively →