SENCR

Across TCGA pan-cancer cohorts, SENCR RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated SENCR data layer.

The strongest signal is observed in mesothelioma (MESO), where higher SENCR RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SENCR expression acts as an unfavorable survival marker, although some lineages such as SKCM and CESC show a favorable association.

MESO, SKCM, and DLBC are the cancer types where SENCR RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Quartile	All	0.179	0.459	<.001	44	view →
SKCM	OS	Quartile	All	0.424	0.243	.001	43	view →
DLBC	DFS	Quartile	All	0.089	1.000	.001	43	view →
CESC	OS	Tertile	IV	0.687	0.230	.022	26	view →
PAAD	OS	Quartile	II,III,IV	0.729	0.480	.006	24	view →
UCEC	OS	Median	All	0.950	0.900	<.001	22	view →
UVM	DFS	Median	All	0.454	0.701	.007	21	view →
THCA	DFS	Median	IV	0.822	0.543	.012	17	view →
KIRP	OS	Median	IV	0.041	0.524	.006	16	view →
HNSC	DFS	Median	IV	0.608	0.475	.006	14	view →
LUSC	OS	Quartile	II,III,IV	0.324	0.619	.011	11	view →
ACC	DFS	Median	All	0.781	0.540	.010	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

SENCR–MESO (OS)

Open the MESO breakdown →