SEMG1

Across TCGA patient cohorts, SEMG1 mutation is significantly associated with the RNA expression of many other genes, with 1,138 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEMG1-associated genes across cancer lineages are RNA5SP297, SAP18P1, and NDUFA4P2. Each is linked with SEMG1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SEMG1-to-partner and partner-to-SEMG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP297 grouped by SEMG1-low versus SEMG1-high in GBM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMG1→partner) and Y-score (partner→SEMG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RNA5SP297 →	+0.377	+4.584	<.001	.007	3	3
BRCA	SAP18P1 →	+0.155	+5.442	<.001	.002	3	3
SKCM	NDUFA4P2 →	+0.048	+1.978	.002	.005	3	3
GBM	MIR548AW →	+0.655	+4.584	<.001	.007	3	2
GBM	MIR4696 →	+0.548	+4.857	<.001	.005	3	2
BRCA	MIR6737 →	+0.351	+4.506	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,138 associations by consensus.

RNA5SP297 by SEMG1 expression — GBM

Explore this box plot interactively →