SEMG1

Across TCGA patient cohorts, SEMG1 mutation is significantly associated with the immune_cell of many other genes, with 7 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible SEMG1-associated genes across cancer lineages are GMP, CD8+ naive T-cells, and Memory B-cells. Each is linked with SEMG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEMG1-to-partner and partner-to-SEMG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GMP grouped by SEMG1-low versus SEMG1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMG1→partner) and Y-score (partner→SEMG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	GMP →	+0.066	+2.316	.049	.044	3	2
SKCM	CD8+ naive T-cells →	-0.020	-1.758	.037	.002	3	1
COAD	Memory B-cells →	+0.046	+3.206	.003	.021	3	1
LUSC	Chondrocytes →	+0.014	+2.694	<.001	.021	3	1
LUSC	pro B-cells →	-0.106	-2.988	.024	.037	3	1
BLCA	MPP →	+0.032	+2.930	.001	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

GMP by SEMG1 expression — BLCA

Explore this box plot interactively →