SEMG1

Across TCGA cell cohorts, SEMG1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SEMG1-associated genes across cancer lineages are DEFB129, OR10V1, and OR13D1. Each is linked with SEMG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEMG1-to-partner and partner-to-SEMG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB129 grouped by SEMG1-low versus SEMG1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMG1→partner) and Y-score (partner→SEMG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DEFB129 →	+0.026	+4.437	<.001	.004	3	1
SKIN	OR10V1 →	+0.016	+4.437	<.001	.004	3	1
LUNG_NSCLC_LUAD	OR13D1 →	+0.022	+3.082	.001	.005	3	1
LUNG_SCLC	PDILT →	+0.136	+5.643	<.001	.002	3	1
LARGE_INTESTINE	REG1B →	+2.047	+3.196	.001	.007	3	1
CNS	SRARP →	+0.101	+4.315	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

DEFB129 by SEMG1 expression — SKIN

Explore this box plot interactively →