SEMA6C

Across TCGA patient cohorts, SEMA6C RNA expression is significantly associated with the protein abundance of many other proteins, with 19,109 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SEMA6C-associated proteins across cancer lineages are VEZF1, SEC23B, and TCIRG1. Each is linked with SEMA6C in more than 5 cancer types. Because this analysis shows association rather than direction, both SEMA6C-to-partner and partner-to-SEMA6C results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SEMA6C versus VEZF1 in GBM, with a Pearson correlation of 0.39.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA6C→partner) and Y-score (partner→SEMA6C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	VEZF1 →	+0.456	+0.830	.001	<.001	3	6
CCRCC	SEC23B →	-0.339	-0.718	<.001	<.001	3	6
GBM	TCIRG1 →	-0.417	-0.534	<.001	<.001	3	6
OV	THBS3 →	+0.690	+1.145	<.001	<.001	3	5
OV	UCHL1 →	+1.117	+0.940	<.001	.004	3	5
BRCA	SMC1A →	+0.205	+0.764	.003	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,109 associations by consensus.

SEMA6C vs VEZF1 — GBM

Explore this scatter interactively →