SEMA6C

Across TCGA patient cohorts, SEMA6C protein abundance is significantly associated with the RNA expression of many other genes, with 3,702 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SEMA6C-associated genes across cancer lineages are HSPB1, SRSF3, and ACVR2B. Each is linked with SEMA6C in more than 2 cancer types. Because this analysis shows association rather than direction, both SEMA6C-to-partner and partner-to-SEMA6C results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SEMA6C versus HSPB1 in UCEC, with a Pearson correlation of -0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA6C→partner) and Y-score (partner→SEMA6C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HSPB1 →	-1.009	-0.372	.001	.005	3	2
GBM	SRSF3 →	+0.467	+0.550	<.001	<.001	3	2
GBM	ACVR2B →	+0.909	+0.510	<.001	<.001	3	2
UCEC	LRRC18 →	-1.174	-0.480	.001	.008	3	2
UCEC	AKR1C3 →	-2.313	-0.456	.001	.007	3	2
UCEC	NUP62CL →	-0.964	-0.420	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,702 associations by consensus.

SEMA6C vs HSPB1 — UCEC

Explore this scatter interactively →