SEMA6C

Across TCGA patient cohorts, SEMA6C mutation is significantly associated with the RNA expression of many other genes, with 1,772 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEMA6C-associated genes across cancer lineages are TRAJ31, CEACAM19, and RNU6-383P. Each is linked with SEMA6C in more than 2 cancer types. Because this analysis shows association rather than direction, both SEMA6C-to-partner and partner-to-SEMA6C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ31 grouped by SEMA6C-low versus SEMA6C-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA6C→partner) and Y-score (partner→SEMA6C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TRAJ31 →	+1.057	+3.407	<.001	.003	3	3
UCEC	CEACAM19 →	-0.797	-2.989	<.001	<.001	3	3
LGG	RNU6-383P →	+0.368	+7.977	<.001	.007	3	2
CESC	RNU6-537P →	+0.368	+5.418	<.001	.005	3	2
CESC	MIR3158-1 →	+0.550	+5.103	<.001	.008	3	2
SKCM	MIR7845 →	+0.178	+2.226	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,772 associations by consensus.

TRAJ31 by SEMA6C expression — COAD

Explore this box plot interactively →